What side effect is common with the use of Adefovir Dipivoxil (Hepsera) when monitoring liver function?

Adefovir Dipivoxil, an antiviral medication primarily used for the treatment of chronic hepatitis B virus infection, is associated with a range of side effects. One notable concern in its use is the potential for renal impairment. This is particularly relevant because adefovir is primarily excreted by the kidneys, and its use can lead to dose-dependent nephrotoxicity, which may manifest as decreased renal function, elevated serum creatinine levels, or renal tubular dysfunction.

Regular monitoring of renal function is essential for patients on adefovir, especially in those with pre-existing renal issues, as well as for those taking other medications that may further affect kidney function. This consideration emphasizes the need for clinicians to assess renal parameters consistently throughout the course of therapy.

The other options listed, such as electrolyte imbalance, hepatic steatosis, and neutropenia, are either less commonly associated with adefovir or pertain to different medications. While these conditions can occur in various clinical settings, renal impairment stands out as a more direct and significant concern linked to the use of adefovir, making it an important factor for healthcare providers to monitor diligently.